Article
High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 17 Jan 2023
Ashley Charles W, Selenica Pier, Patel Juber, Wu Michelle, Nincevic Josip, Lakhman Yulia, Zhou Qin, Shah Ronak H, Berger Michael F, Da Cruz Paula Arnaud, Brown David N, Marra Antonio, Iasonos Alexia, Momeni-Boroujeni Amir, Alektiar Kaled M, Long Roche Kara, Zivanovic Oliver, Mueller Jennifer J, Zamarin Dmitriy, Broach Vance A, Sonoda Yukio, Leitao Mario M, Friedman Claire F, Jewell Elizabeth, Reis-Filho Jorge S, Ellenson Lora H, Aghajanian Carol, Abu-Rustum Nadeem R, Cadoo Karen, Weigelt Britta
Abstract excerpt
PURPOSE: We sought to determine whether sequencing analysis of circulating cell-free DNA (cfDNA) in patients with prospectively accrued endometrial cancer captures the mutational repertoire of the primary lesion and allows for disease monitoring. EXPERIMENTAL DESIGN: Peripheral blood was prospectively collected from 44 newly diagnosed patients with endometrial cancer over a 24-month period (i.e., baseline,...
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