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Genome-wide association study identifies protective genetic factors in active blood donors against multiple diseases.

European journal of human genetics : EJHG - 1 Jun 2026

Clancy Jonna, Toivonen Jarkko, Lauronen Jouni, Partanen Jukka, Arvas Mikko, Ritari Jarmo

Abstract excerpt

The healthy donor effect (HDE) refers to the lower mortality observed among blood donors compared to the general population. While HDE arises due to healthier individuals being more likely to donate, the extent to which it is influenced by genetic differences remains unclear. To elucidate the genetic basis of HDE, we conducted a genome-wide association study (GWAS) involving 53,688 active blood donors with...

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PMID: 42045633
DOI: 10.1038/s41431-026-02100-2

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