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Article

A genome-wide association study of alloimmunization in the TOPMed OMG-SCD cohort identifies a locus on chromosome 12.

Transfusion - 1 Sept 2024

Sun Quan, Karafin Matthew S, Garrett Melanie E, Li Yun, Ashley-Koch Allison, Telen Marilyn J

Abstract excerpt

BACKGROUND: Red cell alloimmunization after exposure to donor red cells is a very common complication of transfusion for patients with sickle cell disease (SCD), resulting frequently in accelerated donor red blood cell destruction. Patients show substantial differences in their predisposition to alloimmunization, and genetic variability is one proposed component. Although several genetic association studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38966903
DOI: 10.1111/trf.17944
PMCID: PMC11499043

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