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Article

Stemness and Survival: CD117+/CD133+ Subpopulations Sustain PI3K Signaling and Drive Imatinib Resistance in Head and Neck Mucosal Melanoma.

Cells - 19 Apr 2026

Hassan Sofie-Yasmin, Santourlidis Simeon, Flanagan Thomas W, Hassan Sarah-Lilly, Zhou He, Schmidt Morna F, Cacchi Claudio, Lammert Matthias Ferdinand, Megahed Mossad, Yazdi Amir Sadegh, Jonigk Danny David, Araúzo-Bravo Marcos J, Brodell Robert T, Facca Sybille, Haikel Youssef, Hassan Mohamed

Abstract excerpt

Head and neck mucosal melanoma (HNMM) arises in the nasal and oral cavities and has the propensity to metastasize to local and distant body sites. HNMM is also notable for its resistance to available therapeutics. The rarity of this disease makes it difficult to conduct large-scale clinical studies to develop standard treatment protocols. In contrast to cutaneous melanoma, c-Kit-dependent pathways are well...

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Share to AC133 Antigen
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imatinib Mesylate

Share to Melanoma

Share to Mucous Membrane

Share to Neoplastic Stem Cells

Share to Phosphatidylinositol 3-Kinases

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Source

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Identifiers

PMID: 42041590
DOI: 10.3390/cells15080721
PMCID: PMC13114392

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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