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Article

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.

Nature genetics - 1 Jul 2005

Reiser Jochen, Polu Krishna R, Möller Clemens C, Kenlan Peter, Altintas Mehmet M, Wei Changli, Faul Christian, Herbert Stephanie, Villegas Ivan, Avila-Casado Carmen, McGee Mary, Sugimoto Hikaru, Brown Dennis, Kalluri Raghu, Mundel Peter, Smith Paula L, Clapham David E, Pollak Martin R

Abstract excerpt

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney. Mutations in genes encoding structural proteins of the podocyte lead to the development of proteinuria, resulting in progressive kidney failure and focal segmental glomerulosclerosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Glomerulosclerosis, Focal Segmental

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Share to Microscopy, Immunoelectron

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Source

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Identifiers

PMID: 15924139
DOI: 10.1038/ng1592
PMCID: PMC1360984

Genes

TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.PMID 15924139Read ↗

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TRPC6 - a new podocyte gene involved in focal segmental glomerulosclerosis.Semantic proximity Read ↗

TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.Semantic proximity Read ↗

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Heterozygous missense variant in TRPC6 in a boy with rapidly progressive infantile nephrotic syndrome associated with diffuse mesangial sclerosis.Semantic proximity Read ↗

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2007 Young Investigator Award: TRP'ing into a new era for glomerular disease.Semantic proximity Read ↗

Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease.Semantic proximity Read ↗

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