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Performance characteristics of chimerism testing by next generation sequencing.

Human immunology - 1 Jan 2022

Cusick Matthew F, Clark Lauren, Tu Thuydung, Goforth John, Zhang Xiaohai, LaRue Bobby, Gutierrez Ryan, Jindra Peter T

Abstract excerpt

Chimerism testing provides informative clinical data regarding the status of a biological sample mixture. For years, this testing was achieved by measuring the peaks of informative short tandem repeat (STR) loci using capillary electrophoresis (CE). With the advent of next generation sequencing (NGS) technology, the quantification of the percentage of donor/recipient mixtures is more easily done using sequence...

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PMID: 34728094
DOI: 10.1016/j.humimm.2021.10.004

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