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Development and performance of a next generation sequencing (NGS) assay for monitoring of mixed chimerism

20 Nov 2020

Abstract excerpt

The aim of this study was to evaluate the performance of a novel NGS-based assay to monitor mixed chimerism (MC) and compare its technical capacity to established techniques for chimerism analysis. Artificial and clinical samples with increasing amounts of patient DNA were compared using real-time PCR detection of indels and SNP, fragment analysis of short-tandem repeats (STR) and NGS analysis of indels....

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PMID: 33227269
DOI: 10.1016/j.cca.2020.10.034

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