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Article

Uncovering the copper(I) binding abilities of a unique fungal metallothionein: characterization of Yarrowia lipolytica MT and its Y54C mutant.

Dalton transactions (Cambridge, England : 2003) - 12 May 2026

Hecel Aleksandra, Briccola Mariano, Freisinger Eva

Abstract excerpt

Metallothioneins (MTs) are a superfamily of cysteine-rich proteins essential for metal homeostasis and detoxification. While mammalian and plant MTs have been extensively characterized, fungal MTs remain comparatively understudied despite their remarkable sequence diversity. In particular, members of the fungal-IV MT family from Yarrowia lipolytica exhibit unusual sequence features, including a conserved CCC...

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PMID: 42028693
DOI: 10.1039/d5dt00689a
PMCID: PMC13107397

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