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Article

Analysis of Metal-Binding Features of the Wild Type and Two Domain-Truncated Mutant Variants of Littorina littorea Metallothionein Reveals Its Cd-Specific Character.

International journal of molecular sciences - 6 Jul 2017

Palacios Òscar, Jiménez-Martí Elena, Niederwanger Michael, Gil-Moreno Selene, Zerbe Oliver, Atrian Sílvia, Dallinger Reinhard, Capdevila Mercè

Abstract excerpt

After the resolution of the 3D structure of the Cd₉-aggregate of the Littorina littorea metallothionein (MT), we report here a detailed analysis of the metal binding capabilities of the wild type MT, LlwtMT, and of two truncated mutants lacking either the N-terminal domain, Lltr2MT, or both the N-terminal domain, plus four extra flanking residues (SSVF), Lltr1MT. The recombinant synthesis and in vitro studies of...

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PMID: 28684668
DOI: 10.3390/ijms18071452
PMCID: PMC5535943

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