Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extramedullary myeloma is genomically complex and characterized by near-universal MAPK pathway alterations.

Blood advances - 12 Aug 2025

Zanwar Saurabh, Novak Joseph, Gonsalves Wilson, Howe Michael, Braggio Esteban, Rajkumar S Vincent, Binder Moritz, Jevremovic Dragan, Dasari Surendra, Kumar Shaji

Abstract excerpt

ABSTRACT: Extramedullary disease (EMD) is associated with an inferior prognosis and lower response rates to conventional multiple myeloma (MM)-directed therapies compared to MM without EMD. A deeper understanding of the molecular landscape and underlying drivers of EMD is essential to identify potential targets for novel therapeutic strategies. To address this, we performed whole-exome sequencing on EMD tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to FAT1 gene

Share to KMT2D gene

Share to Genomics

Share to MAP Kinase Signaling System

Share to Multiple Myeloma

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40367415
DOI: 10.1182/bloodadvances.2025016619
PMCID: PMC12337168

Genes

EMD
ARID1A
BRAF
CDKN2C
EP300
FAT1
KMT2C
KMT2D
KRAS
MAX
MYC
NRAS
ROBO1
ROBO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extramedullary myeloma is genomically complex and characterized by near-universal MAPK pathway alterations.PMID 40367415Read ↗

Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors.Semantic proximity Read ↗

Integration of clinical outcomes and molecular features in extramedullary disease in multiple myeloma.Semantic proximity Read ↗

Genetic Abnormalities in Extramedullary Multiple MyelomaSemantic proximity Read ↗

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.Semantic proximity Read ↗

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.Semantic proximity Read ↗

Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathwaysSemantic proximity Read ↗

Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistanceSemantic proximity Read ↗

A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.Semantic proximity Read ↗

Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling moleculesSemantic proximity Read ↗

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.Semantic proximity Read ↗

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass StudySemantic proximity Read ↗

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.