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Article

Dolutegravir developmental toxicity is mitigated by magnesium and folate in zebrafish embryos.

Disease models & mechanisms - 1 May 2026

Cabrera Robert M, Mohamed Ahmed, Minowa Ryoko, Neugebauer Katheryn A, Gorelick Daniel A

Abstract excerpt

Integrase strand transfer inhibitors have transformed human immunodeficiency virus (HIV) therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity, and its teratogenic mechanism remains unclear. Here, we used zebrafish to dissect DTG toxicity during early vertebrate development. DTG exposure from 2-4 h post-fertilization (hpf) to 24 hpf produced high mortality and...

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Identifiers

PMID: 42021547
DOI: 10.1242/dmm.052632
PMCID: PMC13267766

Genes

FOLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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