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Dolutegravir and Folic Acid Interaction during Neural System Development in Zebrafish Embryos

24 Apr 2024

Abstract excerpt

Dolutegravir (DTG) is one of the most prescribed antiretroviral drugs for treating people with HIV infection, including women of child-bearing potential or pregnant. Nonetheless, neuropsychiatric symptoms are frequently reported. Early reports suggested that, probably in relation to folic acid (FA) shortage, DTG may induce neural tube defects in infants born to women taking the drug during pregnancy. Subsequent...

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PMID: 38731859
DOI: 10.3390/ijms25094640

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