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Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta

23 Dec 2021

Abstract excerpt

BACKGROUND: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta. This study investigates the effect of dolutegravir (DTG) exposure on the functional expression of the reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor-α (FRα)...

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Identifiers

PMID: 34954655
DOI: 10.1016/j.ebiom.2021.103771

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