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Article

A targeted circulating tumor DNA landscape of copy number aberrations in large B-cell lymphomas.

Leukemia - 1 Jul 2026

Arffman Maare, Meriranta Leo, Jørgensen Judit, Karjalainen-Lindsberg Marja-Liisa, Beiske Klaus, Pedersen Mette, Drott Kristina, Fluge Øystein, Jyrkkiö Sirkku, Brown Peter, Holte Harald, Leppä Sirpa

Abstract excerpt

The utility of circulating tumor DNA (ctDNA) for mutational genotyping, pretreatment prognostication, and assessment of molecular response is well established in patients with aggressive large B-cell lymphoma (LBCL). Here, we have applied targeted panel and duplex sequencing of plasma ctDNA to study copy number aberrations (CNAs) along with mutational landscapes in 123 uniformly treated patients with high-risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 42020781
DOI: 10.1038/s41375-026-02955-w
PMCID: PMC13323072

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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