Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA.

doi:10.1126/scitranslmed.aai8545

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Article

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA.

Science translational medicine - 9 Nov 2016

Scherer Florian, Kurtz David M, Newman Aaron M, Stehr Henning, Craig Alexander F M, Esfahani Mohammad Shahrokh, Lovejoy Alexander F, Chabon Jacob J, Klass Daniel M, Liu Chih Long, Zhou Li, Glover Cynthia, Visser Brendan C, Poultsides George A, Advani Ranjana H, Maeda Lauren S, Gupta Neel K, Levy Ronald, Ohgami Robert S, Kunder Christian A, Diehn Maximilian, Alizadeh Ash A

Abstract excerpt

Patients with diffuse large B cell lymphoma (DLBCL) exhibit marked diversity in tumor behavior and outcomes, yet the identification of poor-risk groups remains challenging. In addition, the biology underlying these differences is incompletely understood. We hypothesized that characterization of mutational heterogeneity and genomic evolution using circulating tumor DNA (ctDNA) profiling could reveal molecular...

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Identifiers

PMID: 27831904
DOI: 10.1126/scitranslmed.aai8545
PMCID: PMC5490494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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