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Article

Genomic Alterations and Tumor Mutation Burden in Merkel Cell Carcinoma.

JAMA network open - 3 Jan 2023

Brazel Danielle, Kumar Priyanka, Doan Hung, Pan Tianyu, Shen Weining, Gao Ling, Moyers Justin T

Abstract excerpt

Importance: Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous neuroendocrine carcinoma with increasing incidence. Cytotoxic chemotherapy and checkpoint inhibitors provide treatment options in the metastatic setting; however, there are no approved or standard of care targeted therapy treatment options. Objective: To identify actionable alterations annotated by the OncoKB database therapeutic...

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Identifiers

PMID: 36602798
DOI: 10.1001/jamanetworkopen.2022.49674
PMCID: PMC9856969

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