Article

A Cell-Autonomous Role for the Vitamin B6 Metabolism Gene <i>PNPO</i> in <i>Drosophila</i> GABAergic Neurons

2025-08-11

Abstract excerpt

In animals, the enzyme pyridox(am)ine 5’-phosphate oxidase (PNPO) is critical for synthesizing the active form of vitamin B6 (VB6), pyridoxal 5’-phosphate (PLP), from inactive vitamers. PLP is a required cofactor for many enzymatic reactions, including the synthesis of GABA and the monoamines. PNPO disruption in humans is associated with an array of epilepsy syndromes, while Drosophila harboring mutations in the...

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Literature Corpus work: c9c8f624-20b0-5696-aa8e-4f131dc208ce
DOI: 10.1101/2025.08.07.669010

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