Article
Assessing allelic dropout and genotype reliability using maximum likelihood.
Genetics - 1 Jan 2002
Miller Craig R, Joyce Paul, Waits Lisette P
Abstract excerpt
A growing number of population genetic studies utilize nuclear DNA microsatellite data from museum specimens and noninvasive sources. Genotyping errors are elevated in these low quantity DNA sources, potentially compromising the power and accuracy of the data. The most conservative method for addressing this problem is effective, but requires extensive replication of individual genotypes. In search of a more...
Topics
- Alleles
- Likelihood Functions
- Reproducibility of Results
- Selection Bias
- Stochastic Processes