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Article

Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants.

GigaScience - 28 Dec 2022

Fu Yunfan, Bedő Justin, Papenfuss Anthony T, Rubin Alan F

Abstract excerpt

BACKGROUND: Evaluating the impact of amino acid variants has been a critical challenge for studying protein function and interpreting genomic data. High-throughput experimental methods like deep mutational scanning (DMS) can measure the effect of large numbers of variants in a target protein, but because DMS studies have not been performed on all proteins, researchers also model DMS data computationally to...

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Identifiers

PMID: 37721410
DOI: 10.1093/gigascience/giad073
PMCID: PMC10506130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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