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Partitioning genetic effects on birthweight at classical human leukocyte antigen loci into maternal and fetal components, using structural equation modelling.

International journal of epidemiology - 1 Feb 2024

Wang Geng, Warrington Nicole M, Evans David M

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms in the human leukocyte antigen (HLA) region in both maternal and fetal genomes have been robustly associated with birthweight (BW) in previous genetic association studies. However, no study to date has partitioned the association between BW and classical HLA alleles into maternal and fetal components. METHODS: We used structural equation modelling (SEM) to estimate the...

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PMID: 37831898
DOI: 10.1093/ije/dyad142
PMCID: PMC10859143

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