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Article

Shared Genetics Implicate Gut Microbiota and Immunity in Anterior Uveitis and Inflammatory Bowel Disease.

Ocular immunology and inflammation - 1 Jul 2026

Li Gangyi, Wang Yuke, Zeng Shun, Li Shuangle

Abstract excerpt

PURPOSE: Anterior uveitis (AU) is a common extraintestinal manifestation of inflammatory bowel disease (IBD). This study investigates the shared genetic architecture and pleiotropic loci between AU and IBD. METHODS: Using large-scale GWAS data from European-ancestry cohorts, we performed LD score regression to assess genetic correlations, two-sample Mendelian randomization for causal inference, and PLACO analysis...

Topics

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Gastrointestinal Microbiome
NOD2 gene
STAT3 gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammatory Bowel Diseases

Polymorphism, Single Nucleotide

Uveitis, Anterior

Source

Identifiers

PMID: 41996359
DOI: 10.1080/09273948.2026.2654978

Genes

JAK2
NOD2
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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