Development and genomic characterization of a diverse HIV-1 variant reference panel for nucleic acid-based testing.

doi:10.1016/j.jcv.2026.105941

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Article

Development and genomic characterization of a diverse HIV-1 variant reference panel for nucleic acid-based testing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2026

Zhao Jiangqin, Li Tianxiong, Huang Hanxia, Servellita Venice, Sotomayor-Gonzalez Alicia, Yakovleva Oksana, Wang Xue, Ragupathy Viswanath, Biswas Santanu, Barilko Patricia, Sun Ethan, Huynh Samantha, Hunsicker Melissa, DeQuach Jessica, Morales Jose D, Highbarger Helene, Dewar Robin L, Porth Cassie, Denny Thomas N, McGivern David R, Chiu Charles Y, Hewlett Indira

Abstract excerpt

BACKGROUND: The high worldwide genetic diversity of HIV poses significant challenges for its detection and diagnosis by nucleic acid testing (NAT). Well-characterized reference panels are important for evaluating the analytical performance of HIV tests. OBJECTIVE: To develop a reference panel for HIV NAT that reflects the genetic diversity of circulating strains. STUDY DESIGN: HIV was cultured from blood...

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Identifiers

PMID: 41990403
DOI: 10.1016/j.jcv.2026.105941
PMCID: PMC13155410

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