Article
Utility of Metagenomic Next-Generation Sequencing for Characterization of HIV and Human Pegivirus Diversity.
PloS one - 1 Jan 2015
Luk Ka-Cheung, Berg Michael G, Naccache Samia N, Kabre Beniwende, Federman Scot, Mbanya Dora, Kaptué Lazare, Chiu Charles Y, Brennan Catherine A, Hackett John
Abstract excerpt
Given the dynamic changes in HIV-1 complexity and diversity, next-generation sequencing (NGS) has the potential to revolutionize strategies for effective HIV global surveillance. In this study, we explore the utility of metagenomic NGS to characterize divergent strains of HIV-1 and to simultaneously screen for other co-infecting viruses. Thirty-five HIV-1-infected Cameroonian blood donor specimens with viral...
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