Article
RNF213 gene mutation in circulating tumor DNA detected by targeted next-generation sequencing in the assisted discrimination of early-stage lung cancer from pulmonary nodules.
Thoracic cancer - 1 Jan 2021
Jiang Ning, Zhou Jie, Zhang Wenhao, Li Peichao, Liu Yu, Shi Hubo, Zhang Chengke, Wang Yunshan, Zhou Chengjun, Peng Chuanliang, Zhang Weiquan, Hao Yingtao, Sun Qifeng, Li Yuliang, Zhao Xiaogang
Abstract excerpt
BACKGROUND: To distinguish early-stage lung cancer from benign disease in pulmonary nodules, especially lesions with ground-glass opacity (GGO), we assessed gene mutations of ctDNA in peripheral blood using targeted next-generation sequencing (NGS). METHODS: Single pulmonary nodule patients without mediastinal lymph nodes and symptoms that were hard to diagnose by chest CT and lung cancer biomarker measurement in...
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