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Article

Healthy sleep, proteomic signatures, and incident depression: associations accounting for genetic risk in an adult cohort.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jun 2026

Peng Shuyi, Guo Yannan, Wang Wanxin, Jiang Guiyu, Liu Qianyu, Lu Ciyong, Zhong Xiali, Guo Lan

Abstract excerpt

OBJECTIVES: We examined associations between healthy sleep patterns and incident depression, accounting for genetic susceptibility, identified related plasma proteins and their mediating role, and explored associations with brain structure. METHODS: Among 39,702 depression-free UK Biobank participants, five healthy sleep factors, plasma proteomic profiles, polygenic risk scores (PRS) for depression, brain...

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PMID: 41989327
DOI: 10.1080/15622975.2026.2656652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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