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Article

Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans.

PLoS biology - 1 Mar 2026

Mi Kai, Guan Lili, Sarker Bandhan, Song Siliang, Zhou Tianjiao, Yi Hongliang, Zhang Jianzhi, Xu Chuan

Abstract excerpt

In eukaryotes, alternative transcription initiation (ATI), alternative splicing (AS), and alternative polyadenylation (APA) result in multiple different transcripts per gene, but the biological significance of the transcript diversity produced remains controversial. Some suggested that this diversity is adaptive, while others contended that it is largely deleterious and arises from molecular errors in...

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Identifiers

PMID: 41988943
DOI: 10.1371/journal.pbio.3003671
PMCID: PMC13001929

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