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Article

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC.

Scientific reports - 3 Jan 2025

Zhou Tao, Zhang Dan Dan, Jin Jiejing, Xie Jinyang, Yu Jianhua, Zhu Chao, Wan Rong

Abstract excerpt

SMAD3, a protein-coding gene, assumes a pivotal role within the transforming growth factor-beta (TGF-β) signaling pathway. Notably, aberrant SMAD3 expression has been linked to various malignancies. Nevertheless, an extensive examination of the comprehensive pan-cancer impact on SMAD3's diagnostic, prognostic, and immunological predictive utility has yet to be undertaken. Bioinformatics methods were employed to...

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Identifiers

PMID: 39753728
DOI: 10.1038/s41598-024-84553-3
PMCID: PMC11698864

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