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Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC.

Scientific reports - 3 Jan 2025

Zhou Tao, Zhang Dan Dan, Jin Jiejing, Xie Jinyang, Yu Jianhua, Zhu Chao, Wan Rong

Abstract excerpt

SMAD3, a protein-coding gene, assumes a pivotal role within the transforming growth factor-beta (TGF-β) signaling pathway. Notably, aberrant SMAD3 expression has been linked to various malignancies. Nevertheless, an extensive examination of the comprehensive pan-cancer impact on SMAD3's diagnostic, prognostic, and immunological predictive utility has yet to be undertaken. Bioinformatics methods were employed to...

Topics

Humans
Smad3 Protein
Carcinoma, Hepatocellular
Prognosis
Liver Neoplasms
Gene Expression Regulation, Neoplastic
DNA Methylation
Biomarkers, Tumor
Computational Biology
Mutation
Cell Line, Tumor

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Identifiers

PMID: 39753728
DOI: 10.1038/s41598-024-84553-3
PMCID: PMC11698864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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