Article
BRAF p.V600E Mutational Status Does Not Correlate with Biological Behavior in Conventional Ameloblastomas: A Disease-Free Survival Analysis.
Head and neck pathology - 19 Mar 2024
Martins-de-Barros Allan Vinícius, da Costa Araújo Fábio Andrey, Faro Tatiane Fonseca, de Aquino Arthur Alves Thomaz, Barbosa Neto Adauto Gomes, da Silva Helker Albuquerque Macedo, de Lima Elker Lene Santos, Muniz Maria Tereza Cartaxo, de Oliveira E Silva Emanuel Dias, de Vasconcelos Carvalho Marianne
Abstract excerpt
BACKGROUND: Dysregulation of the MAPK pathway appears to exert a pivotal role in the pathogenesis of ameloblastomas, since BRAF p.V600E has been reported in over 65% of the tumors. Therefore, the purpose of this study was to investigate whether the BRAF p.V600E is related to biological behavior a...
Topics
- Humans
- Male
- Female
- Disease-Free Survival
- Ameloblastoma
- Proto-Oncogene Proteins B-raf
- Syndecan-1
- Retrospective Studies
- Mutation