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Article

A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2026

Wang Yuxuan, Xie Jiajun, Pasca Sergiu, Popoli Maria, Ptak Janine, Dobbyn Lisa, Silliman Natalie, Paul Suman, Jones Richard J, Levis Mark J, Curtis Samuel D, Douville Christopher, Shams Cynthia, Guo Matthew Z, Mo Shirley, Gocke Christopher D, Malek Sami N, Bollard Catherine M, Bettegowda Chetan, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas, Gondek Lukasz P

Abstract excerpt

Allogeneic hematopoietic cell transplantation is the only curative option for many patients with acute myeloid leukemia (AML). In the current study, we designed and implemented a personalized assay, called v96, incorporating up to 96 mutations in 30 AML patients undergoing transplantation. The assay was performed on DNA derived from cells isolated from the bone marrow as well as in cell-free plasma. All 30 (100%)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41980102
DOI: 10.1073/pnas.2537987123
PMCID: PMC13099560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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