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Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report.

Pediatric blood & cancer - 1 Jul 2026

Waligorski Natalie, Ronsley Rebecca, Stasi Shannon M, Stevens Jeffrey, Rudzinski Erin R, Lockwood Christina M, Leary Sarah E S, Cole Bonnie L, Ting Michelle A, Paulson Vera

Abstract excerpt

OBJECTIVE: To evaluate the diagnostic yield and utility of universal paired tumor-normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer predisposition assessment. METHODS: From May 2021 to November 2022,...

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PMID: 41964503
DOI: 10.1002/1545-5017.70326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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