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Article

Clinical challenges of cancer predisposition syndromes with pediatric central nervous system tumors: a single-center study.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 22 Nov 2025

Kubota Hirohito, Fukuoka Kohei, Arakawa Yuki, Uchihara Yoshinori, Takita Junko, Ohashi Hirofumi, Kurihara Jun, Koh Katsuyoshi

Abstract excerpt

INTRODUCTION: Recent developments in genetic testing have demonstrated that cancer predisposition syndrome (CPS) is present in approximately 15% of pediatric central nervous system (CNS) tumors; however, the optimal eligibility and timing of germline genetic testing in these patients have not been determined yet. METHODS: We retrospectively examined the clinical and genetic characteristics of pediatric CNS tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41273437
DOI: 10.1007/s00381-025-06976-1

Genes

DGCR8
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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