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Article

Gastroesophageal reflux disease and childhood asthma: A bidirectional two-sample Mendelian randomization study.

Medicine - 10 Apr 2026

Ding Lianfu, Xiong Lijuan, Chen Qingfa, Liu Hong, Li Qing

Abstract excerpt

Gastroesophageal reflux disease (GERD) commonly coexists with childhood asthma, but observational evidence is confounded by adiposity, medications, and shared environments, and reverse causation cannot be excluded. Mendelian randomization (MR), using germline variants as instruments, can mitigate confounding and reverse causation. We conducted a bidirectional two-sample MR to clarify whether genetically proxied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41961722
DOI: 10.1097/MD.0000000000048171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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