Causal Effects of Gastroesophageal Reflux on Chronic Rhinosinusitis: A Bidirectional Two-Sample Mendelian Randomization Study.

doi:10.1111/coa.14251

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Article

Causal Effects of Gastroesophageal Reflux on Chronic Rhinosinusitis: A Bidirectional Two-Sample Mendelian Randomization Study.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery - 1 Mar 2025

Xin Xiang, Yang Yang, Xuelei Li, Hongbing Yao, Xinye Tang, Jia Liang

Abstract excerpt

INTRODUCTION: Observational studies have shown a bidirectional association between gastroesophageal reflux (GER) and chronic rhinosinusitis (CRS) or chronic rhinitis (CR), but it is not clear whether this association is causal. OBJECTIVES: This study was to investigate the causality between GER and CRS or CR using bidirectional two-sample Mendelian randomization (MR) analysis. METHODS: Using pooled data from...

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PMID: 39492462
DOI: 10.1111/coa.14251

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