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Article

Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.

American journal of respiratory and critical care medicine - 15 Jan 2023

Ahn Kwangmi, Penn Raymond B, Rattan Satish, Panettieri Reynold A, Voight Benjamin F, An Steven S

Abstract excerpt

Rationale: Gastroesophageal reflux disease (GERD) is commonly associated with atopic disorders, but cause-effect relationships remain unclear. Objectives: We applied Mendelian randomization analysis to explore whether GERD is causally related to atopic disorders of the lung (asthma) and/or skin (atopic dermatitis [AD]). Methods: We conducted two-sample bidirectional Mendelian randomization to infer the magnitude...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36214830
DOI: 10.1164/rccm.202205-0951OC
PMCID: PMC9893317

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