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Article

ABCB1 Polymorphisms Influence on Temozolomide Resistance and Overall Survival in Glioblastoma Patients: A Systematic Review of Clinical Evidence.

Journal of cellular and molecular medicine - 1 Apr 2026

De Luca Fabiola, Mannino Deborah, Capra Anna Paola, Ciappina Giuliana, Donato Marco, Caruso Giuseppe, Esposito Emanuela, Ardizzone Alessio

Abstract excerpt

Glioblastoma (GB), defined as IDH-wildtype CNS WHO grade 4 tumour according to the 2021 WHO classification of CNS tumours, remains a uniformly lethal malignancy in which the efficacy of temozolomide (TMZ) continues to be constrained by both intrinsic tumur biology and the pharmacological barrier imposed by the blood-brain barrier (BBB). Given the central role of the ABCB1 (MDR1/P-glycoprotein) efflux transporter...

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Topics

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Share to Antineoplastic Agents, Alkylating
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Drug Resistance, Neoplasm

Share to MGMT gene

Share to Glioblastoma

Share to Polymorphism, Single Nucleotide

Share to Temozolomide

Source

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Identifiers

PMID: 41957561
DOI: 10.1111/jcmm.71130
PMCID: PMC13065491

Genes

ABCB1
MGMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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ABCB1 Polymorphisms Influence on Temozolomide Resistance and Overall Survival in Glioblastoma Patients: A Systematic Review of Clinical Evidence.PMID 41957561Read ↗

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