Pharmacogenetics of ATP binding cassette transporter MDR1(1236C>T) gene polymorphism with glioma patients receiving Temozolomide-based chemoradiation therapy in Indian population.

doi:10.1038/s41397-021-00206-y

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Pharmacogenetics of ATP binding cassette transporter MDR1(1236C>T) gene polymorphism with glioma patients receiving Temozolomide-based chemoradiation therapy in Indian population.

The pharmacogenomics journal - 1 Apr 2021

Munisamy Murali, Munisamy Srinivasan, Kumar Julka Pramod, Jose Anmi, Thomas Levin, Baburaj Gayathri, Subbiah Vivekanandhan

Abstract excerpt

Temozolomide (TMZ), an alkylating agent with a broad-spectrum antitumor activity, ability to cross blood-brain barrier (BBB), shown to be effective against malignant glioma. This study aims to investigate the effect of 1236C>T (rs1128503) single-nucleotide gene polymorphisms of ABCB1 (MDR1) in north-Indian patients diagnosed with glioma undergoing TMZ-based chemoradiotherapy. Genotyping was performed in 100...

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PMID: 33589792
DOI: 10.1038/s41397-021-00206-y

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