Article
High serum ferritin is associated with genetic instability in myelodysplastic neoplasms.
Journal of cancer research and clinical oncology - 9 Apr 2026
Ganster Christina, Treiber Hannes, Westhofen Gina, Beier Fabian, Rassaf Tienush, Al-Ali Haifa Kathrin, Stuhlmann Reingard, Glass Bertram, Bacher Ulrike, Shirneshan Katayoon, Brümmendorf Tim H, Germing Ulrich, Gattermann Norbert, Haase Detlef
Abstract excerpt
PURPOSE: Serum ferritin is an independent prognostic marker in myelodysplastic neoplasms (MDS) and serves as a surrogate parameter for iron overload. Oxidative stress derived from iron overload may induce genomic damage, thereby promoting genetic instability and disease progression in MDS. We aimed to evaluate a possible association between iron overload via serum ferritin and various parameters for genetic...
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