Article
Short telomere length and its correlation with gene mutations in myelodysplastic syndrome.
Journal of hematology & oncology - 28 Jul 2016
Hwang Sang Mee, Kim Seon Young, Kim Jung Ah, Park Hee-Sue, Park Si Nae, Im Kyongok, Kim Kwantae, Kim Sung-Min, Lee Dong Soon
Abstract excerpt
BACKGROUND: Telomere erosion can lead to genomic instability and cancer progression. It has been suggested that the shortest telomere, not the average telomere length (TL), is critical for cell viability. Some studies have shown shorter TL in myelodysplastic syndrome (MDS) patients but the critically short telomeres, the variability of TL within individual patient has not been evaluated. Thus, we aimed to...
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