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Article

Opportunistic Screening of High-Risk Breast Cancer Variants in Hospital Biobank Setting.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Jun 2026

Pehrsson Minja, Jakkula Eveliina, Ala-Kulju Kimmo, Loukola Anu, Niemelä Janita, Löfman Katja, Anttonen Anna-Kaisa, Meretoja Tuomo, Mattson Johanna, Lappalainen Maarit, Pöyhönen Minna, Carpén Olli

Abstract excerpt

BACKGROUND: Genetic data accumulating in biobanks provide novel possibilities for personalized medicine through opportunistic screening. In this pilot study, we evaluated the applicability and impact of screening pathogenic variants (PVs) of BRCA1, BRCA2, and PALB2 genes predisposing to hereditary breast and ovarian cancer (HBOC), from biobank samples. METHODS: PVs of BRCA1, BRCA2, and PALB2 were screened from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41954593
DOI: 10.1158/1055-9965.EPI-25-1757
PMCID: PMC13227088

Genes

BRCA1
BRCA2
PALB2
HBB
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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