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Article

Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility.

Genome research - 1 Mar 2012

Cassa Christopher A, Savage Sarah K, Taylor Patrick L, Green Robert C, McGuire Amy L, Mandl Kenneth D

Abstract excerpt

There is an emerging consensus that when investigators obtain genomic data from research participants, they may incur an ethical responsibility to inform at-risk individuals about clinically significant variants discovered during the course of their research. With whole-exome sequencing becoming commonplace and the falling costs of full-genome sequencing, there will be an increasingly large number of variants...

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PMID: 22147367
DOI: 10.1101/gr.127845.111
PMCID: PMC3290777

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