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Returning individual genomic results to population-based cohort study participants with BRCA1/2 pathogenic variants.

Breast cancer (Tokyo, Japan) - 1 Jan 2023

Ohneda Kinuko, Hamanaka Yohei, Kawame Hiroshi, Fuse Nobuo, Nagami Fuji, Suzuki Yoichi, Yamaguchi-Kabata Yumi, Shimada Muneaki, Masamune Atsushi, Aoki Yoko, Ishida Takanori, Yamamoto Masayuki

Abstract excerpt

BACKGROUND: Recent advances in human genome research have provided evidence for genotype-phenotype associations, pathogenicity, and clinical actionability of variants and genomic risk prediction of disease. However, the return of individual genomic results to healthy individuals is fraught with ethical and practical complexity. METHODS: Individual genomic results were returned to BRCA1/2 pathogenic variant (PV)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36161580
DOI: 10.1007/s12282-022-01404-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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