Article
Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2018
Buchanan Adam H, Manickam Kandamurugu, Meyer Michelle N, Wagner Jennifer K, Hallquist Miranda L G, Williams Janet L, Rahm Alanna Kulchak, Williams Marc S, Chen Zong-Ming E, Shah Chaitali K, Garg Tullika K, Lazzeri Amanda L, Schwartz Marci L B, Lindbuchler D'Andra M, Fan Audrey L, Leeming Rosemary, Servano Pedro O, Smith Ashlee L, Vogel Victor G, Abul-Husn Noura S, Dewey Frederick E, Lebo Matthew S, Mason-Suares Heather M, Ritchie Marylyn D, Davis F Daniel, Carey David J, Feinberg David T, Faucett W Andrew, Ledbetter David H, Murray Michael F
Abstract excerpt
PurposeThe clinical utility of screening unselected individuals for pathogenic BRCA1/2 variants has not been established. Data on cancer risk management behaviors and diagnoses of BRCA1/2-associated cancers can help inform assessments of clinical utility.MethodsWhole-exome sequences of participants in the MyCode Community Health Initiative were reviewed for pathogenic/likely pathogenic BRCA1/2 variants....
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