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Genomic Alteration Patterns Across Histological Grades in BRAF p.V600E-Mutant Gliomas and Glioneuronal Tumors: An Analysis of 15 Cases.

Pathology international - 1 Apr 2026

Yamada Seiji, Takimoto Tetsuya, Ikeda Mina, Sugihara Eiji, Yamaguchi Junya, Deguchi Shoichi, Aoki Kosuke, Ohka Fumiharu, Motomura Kazuya, Takeda Mayu, Ohba Shigeo, Minamiguchi Sachiko, Karube Kennosuke, Saito Ryuta, Hirose Yuichi, Saya Hideyuki

Abstract excerpt

BRAF p.V600E-mutant gliomas and glioneuronal tumors comprise a wide clinicopathological spectrum, yet the relationship between genomic alteration burden and histological grade remains incompletely defined. We analyzed 15 BRAF p.V600E-mutant gliomas and glioneuronal tumors across histological grades using the PleSSision Rapid sequencing platform. Single-nucleotide variants (SNVs) and copy-number alterations were...

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Identifiers

PMID: 41952308
DOI: 10.1111/pin.70113

Genes

BRAF
CDKN2A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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