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Article

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.

Nature genetics - 1 Feb 2021

Stein Murray B, Levey Daniel F, Cheng Zhongshan, Wendt Frank R, Harrington Kelly, Pathak Gita A, Cho Kelly, Quaden Rachel, Radhakrishnan Krishnan, Girgenti Matthew J, Ho Yuk-Lam Anne, Posner Daniel, Aslan Mihaela, Duman Ronald S, Zhao Hongyu, Polimanti Renato, Concato John, Gelernter Joel

Abstract excerpt

We conducted genome-wide association analyses of over 250,000 participants of European (EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health record-validated post-traumatic stress disorder (PTSD) diagnosis and quantitative symptom phenotypes. Applying genome-wide multiple testing correction, we identified three significant loci in European case-control analyses and 15 loci in...

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Identifiers

PMID: 33510476
DOI: 10.1038/s41588-020-00767-x
PMCID: PMC7972521

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