Article
Discovery and optimization of 1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide derivatives as USP1 inhibitors for BRCA1-mutant cancer treatment.
Bioorganic chemistry - 5 Jul 2026
Zhao Tuotuo, Chen Congwei, An Yuxiang, Xu Yuting, Guo Yong, Yao Shanyan, Zhou Baobao, Chen Yi, Duan Wenhu, Guan Zhiyu, Tang Wei, Zhang Hefeng
Abstract excerpt
Ubiquitin-specific protease 1 (USP1) plays a critical role in deubiquitinating key protein complexes involved in the DNA damage response (DDR). Inhibition of USP1 has been shown to induce synthetic lethality in BRCA1-mutant cancers, making it an attractive anticancer therapeutic target. In this study, a series of 1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide derivatives were designed and synthesized as novel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.