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USP24 promotes drug resistance during cancer therapy

12 Apr 2021

Abstract excerpt

Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP-binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out...

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PMID: 33846536
DOI: 10.1038/s41418-021-00778-z

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