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Article

Mapping the mutational terrain of lung adenocarcinoma: A Danish cohort study of 880 patients.

Cancer treatment and research communications - 1 Jan 2026

Georgsen Jeanette Bæhr, Jakobsen Maria Vad, Meldgaard Peter, Lade-Keller Johanne, Jepsen Peter, Nielsen Patricia Switten, Dyrborg Lena, Steiniche Torben

Abstract excerpt

BACKGROUND: In this population-based cohort, we examined the prevalence of targetable genomic alterations and characterized KRAS subtypes in relation to co-mutations, PD-L1 expression, treatment, and survival. MATERIALS AND METHODS: A total of 880 patients diagnosed with lung adenocarcinoma in Central Denmark in 2020-2021 underwent reflex next-generation sequencing using a 22-gene panel. RESULTS: KRAS mutations...

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Identifiers

PMID: 41950707
DOI: 10.1016/j.ctarc.2026.101202

Genes

KRAS
SMAD4
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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