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Article

Association of Human Leucocyte Antigen with Tacrolimus Pharmacokinetics in Renal Transplant Patients.

Pharmacotherapy - 1 May 2026

Hemani Rashmi J, Joreja Amit S, Shete Nitiraj B, Srivastava Ratika, Soni Shailesh M, Gang Shishir D, Konnur Abhijit M, Hegde Umapati N, Patel Hardik B, Mukhopadhyay Banibrata N, Raval Manan A, Pandey Sachchida Nand

Abstract excerpt

INTRODUCTION: Tacrolimus (Tac or FK-506) is an immunosuppressive agent that inhibits T-cell activation and proliferation. It has a narrow therapeutic index and shows inter-patient variabilities in its plasma concentration. Human Leucocyte Antigen (HLA) plays a major role in immune regulation and function. Tac inhibits the T-cells, and HLA antigens are expressed in T-cells. The objective of this study was to...

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PMID: 41947660
DOI: 10.1002/phar.70141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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