ACE2 Polymorphisms and COVID-19 Severity: A Study on Their Relationship with Clinical Findings.

doi:10.1177/19450265261440903

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ACE2 Polymorphisms and COVID-19 Severity: A Study on Their Relationship with Clinical Findings.

Genetic testing and molecular biomarkers - 1 Apr 2026

Çekin Nilgün, Akin Seyda, Pinarbasi Ergun, Dogan Halef Okan

Abstract excerpt

OBJECTIVE: An epidemic of acute pneumonia caused by SARS-CoV-2 spread rapidly worldwide in December 2019. The first interaction between the virus and the host cell occurs via the binding of the spike (S) protein to the ACE2 receptor. ACE2 gene expression correlates with COVID-19 severity, and certain polymorphisms may alter expression or susceptibility. METHODS: This study investigated ACE2 rs200180615,...

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PMID: 41947332
DOI: 10.1177/19450265261440903

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