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Article

Uncovering polygenic and local genetic overlap between sarcopenia and Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 May 2026

Ding Kaixi, Jiang Wei, Lei Ming, Gao Yongxiang

Abstract excerpt

BackgroundSarcopenia and Alzheimer's disease (AD) are prevalent comorbidities in older adults. Their common genetic basis remains unclear.ObjectiveUtilizing Genomic Structural Equation Modeling, we used European-ancestry genome-wide association study (GWAS) summary statistics to model sarcopenia-related traits. Multiple AD GWAS datasets and the sarcopenia GWAS dataset were used to conduct cross-trait...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41940827
DOI: 10.1177/13872877261436016

Genes

FEZ2
ETHE1
PHLDB3
PINLYP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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